liver toxicity-related compounds Oxidative Stress increase AOP144 cardiovascular NM toxicity AOP for lung toxicity KE for lung toxicity AOP173 references inflammation chemicals MIE by DAPI KE /AOP DAPI assay Neutrophils or DAPI genes carbon nanotubes metal oxides Adverse outcomes of AOP AOP173 AOP451 polyethylene Bio events per KE AOP Endorsed AOP Under review AOP Under development AOP withtout OECD status